A universal pathway for amyloid nucleus and precursor formation for insulin.

@article{Nayak2009AUP,
  title={A universal pathway for amyloid nucleus and precursor formation for insulin.},
  author={Arpan Nayak and Mirco Sorci and Susan Krueger and Georges Belfort},
  journal={Proteins},
  year={2009},
  volume={74 3},
  pages={556-65}
}
To help identify the etiological agents for amyloid-related diseases, attention is focused here on the fibrillar precursors, also called oligomers and protofibrils, and on modeling the reaction kinetics of the formation of the amyloid nucleus. Insulin is a favored model for amyloid formation, not only because amyloidosis can be a problem in diabetes, but also because aggregation and fibrillation causes problems during production, storage, and delivery. Small angle neutron scattering (SANS) is… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 20 extracted citations

Monitoring Insulin Aggregation via Capillary Electrophoresis

International journal of molecular sciences • 2011
View 3 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 73 references

Mechanisms of prion protein assembly into amyloid.

Proceedings of the National Academy of Sciences of the United States of America • 2008

Nucleation of protein fibrillation by nanoparticles.

Proceedings of the National Academy of Sciences of the United States of America • 2007
View 1 Excerpt

Similar Papers

Loading similar papers…