A universal influenza A vaccine based on adenovirus expressing matrix-2 ectodomain and nucleoprotein protects mice from lethal challenge.

@article{Zhou2010AUI,
  title={A universal influenza A vaccine based on adenovirus expressing matrix-2 ectodomain and nucleoprotein protects mice from lethal challenge.},
  author={Dongming Zhou and Te-Lang Wu and Marcio O. Lasaro and Brian P Latimer and Elizabeth M Parzych and A. F. A. Bian and Yan Li and Hua Li and Jan Erikson and Zhiquan Xiang and Hildegund C J Ertl},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2010},
  volume={18 12},
  pages={
          2182-9
        }
}
A universal influenza vaccine, designed to induce broadly cross-reactive immunity against current and future influenza A virus strains, is in critical demand to reduce the need for annual vaccinations with vaccines chosen upon predicting the predominant circulating viral strains, and to ameliorate the threat of cyclically occurring pandemics that have, in the past, killed tens of millions. Here, we describe a vaccine regimen based on sequential immunization with two serologically distinct… CONTINUE READING
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