A universal T cell epitope-containing peptide from hepatitis B surface antigen can enhance antibody specific for HIV gp120.

@article{Greenstein1992AUT,
  title={A universal T cell epitope-containing peptide from hepatitis B surface antigen can enhance antibody specific for HIV gp120.},
  author={Julia L. Greenstein and V C Schad and W H Goodwin and Arnd B E Brauer and Brenda K. Bollinger and Ruth Chin and M C Kuo},
  journal={Journal of immunology},
  year={1992},
  volume={148 12},
  pages={3970-7}
}
Peptide-based vaccines that directly target T cell or B cell epitopes may have significant advantages over conventional vaccines. Further, synthetic chimeric peptides that combine strong T cell epitopes with poorly immunogenic, but immunodominant, B cell epitopes or strain-conserved B cell epitopes may be useful in eliciting antibody to such important regions. Here we characterize a human T cell epitope analyzed in 54 individuals immunized with a hepatitis B virus surface Ag vaccine. Primary… CONTINUE READING

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