A universal RNAi-based logic evaluator that operates in mammalian cells

@article{Rinaudo2007AUR,
  title={A universal RNAi-based logic evaluator that operates in mammalian cells},
  author={Keller Rinaudo and Leonidas Bleris and Rohan Maddamsetti and Sairam Subramanian and R. Weiss and Y. Benenson},
  journal={Nature Biotechnology},
  year={2007},
  volume={25},
  pages={795-801}
}
Molecular automata that combine sensing, computation and actuation enable programmable manipulation of biological systems. We use RNA interference (RNAi) in human kidney cells to construct a molecular computing core that implements general Boolean logic to make decisions based on endogenous molecular inputs. The state of an endogenous input is encoded by the presence or absence of 'mediator' small interfering RNAs (siRNAs). The encoding rules, combined with a specific arrangement of the siRNA… Expand
433 Citations
Logic integration of mRNA signals by an RNAi-based molecular computer
  • 59
  • PDF
DNA computation in mammalian cells: microRNA logic operations.
  • 126
Engineering RNAi circuits.
  • 3
RNA-based computation in live cells.
  • Y. Benenson
  • Biology, Medicine
  • Current opinion in biotechnology
  • 2009
  • 67
  • PDF
RNA-based gene circuits for cell regulation
  • 9
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 34 REFERENCES
Programmable ligand-controlled riboregulators of eukaryotic gene expression
  • 342
  • PDF
BioLogic gates enable logical transcription control in mammalian cells
  • 175
  • PDF
Toward in vivo Digital Circuits
  • 123
Directed evolution of a genetic circuit
  • 439
  • PDF
RNA synthetic biology
  • 332
  • PDF
On schemes of combinatorial transcription logic
  • N. Buchler, U. Gerland, T. Hwa
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 2003
  • 616
  • PDF
Small non-coding RNAs as magic bullets.
  • F. Eckstein
  • Biology, Medicine
  • Trends in biochemical sciences
  • 2005
  • 44
  • PDF
...
1
2
3
4
...