A unique signature identifies a family of zinc-dependent metallopeptidases.

@article{Jongeneel1989AUS,
  title={A unique signature identifies a family of zinc-dependent metallopeptidases.},
  author={C. Victor Jongeneel and Jean Bouvier and Amos Bairoch},
  journal={FEBS letters},
  year={1989},
  volume={242 2},
  pages={211-4}
}
The primary sequence motif HExxH has been found in many zinc-dependent endopeptidases. We show that a larger signature comprising this sequence is common to most of the known zinc-dependent endopeptidases, and that the presence of the signature can be indicative of membership in the family. A search of the protein sequence databases for entries containing the signature retrieved several unexpected potential zinc endopeptidases.