A unique role of the DNA fragmentation factor in maintaining genomic stability.

Abstract

DNA fragmentation is a hallmark of apoptosis (programmed cell death). However, the biological function of apoptotic DNA fragmentation remains unclear. Here, we show that DNA fragmentation factor plays an important role for maintaining genomic stability. Inhibition or loss of the DNA fragmentation factor (DFF)/caspase-activated DNase (CAD), whose nuclease… (More)

Topics

7 Figures and Tables

Cite this paper

@article{Yan2006AUR, title={A unique role of the DNA fragmentation factor in maintaining genomic stability.}, author={Bin Yan and Huili Wang and Yuanlin Peng and Ye Hu and He Wang and Xiuwu Zhang and Qi Chen and Joel S. Bedford and Mark W. Dewhirst and Chuan-Yuan Li}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2006}, volume={103 5}, pages={1504-9} }