A unique role for the Rb protein in controlling E2F accumulation during cell growth and differentiation.

@article{Ikeda1996AUR,
  title={A unique role for the Rb protein in controlling E2F accumulation during cell growth and differentiation.},
  author={Masa A Ikeda and Laszlo Jakoi and J. R. Nevins},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1996},
  volume={93 8},
  pages={3215-20}
}
Examination of the interactions involving transcription factor E2F activity during cell growth and terminal differentiation suggests distinct roles for Rb family members in the regulation of E2F accumulation. The major species of E2F in quiescent cells is a complex containing the E2F4 product in association with the Rb-related p130 protein. As cells enter the cell cycle, this complex disappears, and there is a concomitant accumulation of free E2F activity of which E2F4 is a major component… CONTINUE READING

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