A unique missense allele of BAF155, a core BAF chromatin remodeling complex protein, causes neural tube closure defects in mice.

@article{Harmacek2014AUM,
  title={A unique missense allele of BAF155, a core BAF chromatin remodeling complex protein, causes neural tube closure defects in mice.},
  author={Laura Harmacek and Dawn E Watkins-Chow and Jianfu Chen and Kenneth L. Jones and William J. Pavan and J. Michael Salbaum and Lee Niswander},
  journal={Developmental neurobiology},
  year={2014},
  volume={74 5},
  pages={483-97}
}
Failure of embryonic neural tube closure results in the second most common class of birth defects known as neural tube defects (NTDs). While NTDs are likely the result of complex multigenic dysfunction, it is not known whether polymorphisms in epigenetic regulators may be risk factors for NTDs. Here we characterized Baf155(msp3) , a unique ENU-induced allele in mice. Homozygous Baf155(mps3) embryos exhibit highly penetrant exencephaly, allowing us to investigate the roles of an assembled, but… CONTINUE READING
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