A unique mechanism of chaperone action: heme regulation of Hap1 activity involves separate control of repression and activation.

@article{Lee2009AUM,
  title={A unique mechanism of chaperone action: heme regulation of Hap1 activity involves separate control of repression and activation.},
  author={Hee Chul Lee and Li Zhang},
  journal={Protein and peptide letters},
  year={2009},
  volume={16 6},
  pages={642-9}
}
The Hsp90 and Hsp70 molecular chaperones play important roles in the folding and proper functioning of diverse cellular proteins, including transcriptional regulators and protein kinases. In yeast, several transcriptional regulators and protein kinases are known to be substrates for Hsp90 and Hsp70 molecular chaperones. The yeast heme activator protein Hap1 promotes transcription of many genes in response to heme. It requires Hsp90 and Hsp70 molecular chaperones for its activity to be precisely… CONTINUE READING

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