A unique isoform of phospholipase Cbeta4 highly expressed in the cerebellum and eye.

@article{Adamski1999AUI,
  title={A unique isoform of phospholipase Cbeta4 highly expressed in the cerebellum and eye.},
  author={Frances M. Adamski and Kirsten M. Timms and B H Shieh},
  journal={Biochimica et biophysica acta},
  year={1999},
  volume={1444 1},
  pages={55-60}
}
We report a unique isoform of PLCbeta4 in rat, PLCbeta4c, that has an additional 37-nucleotide exon inserted between nucleotides 3459-3460 of the previously published PLCbeta4a coding sequence. This insertion results in replacement of 22 amino acid residues at the carboxyl terminal tail of PLCbeta4a with 41 unique residues. A human EST for PLCbeta4 also contains this exon and this exon was mapped to within a 5.5 kb intron of the human PLCbeta4 gene. PLCbeta4c is the third PLCbeta4 isoform to be… CONTINUE READING