A unique interhelical insertion in plasminogen activator inhibitor-2 contains three glutamines, Gln83, Gln84, Gln86, essential for transglutaminase-mediated cross-linking.

@article{Jensen1994AUI,
  title={A unique interhelical insertion in plasminogen activator inhibitor-2 contains three glutamines, Gln83, Gln84, Gln86, essential for transglutaminase-mediated cross-linking.},
  author={Poul Henning Jensen and Ellen Sch{\"u}ler and Graeme Woodrow and Michael. Richardson and Neil Howard Goss and Peter H{\o}jrup and Torben E. Petersen and Lone Kjar Rasmussen},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 21},
  pages={
          15394-8
        }
}
Plasminogen activator inhibitor type 2 (PAI-2) prevents fibrinolysis by blocking plasminogen activators. It is expressed principally by trophoblast cells and macrophages. PAI-2 in trophoblast membranes has been found cross-linked to large complexes apparently catalyzed by trophoblast transglutaminase (Jensen, P. H., Lorand, L., Ebbesen, P., and Gliemann, J. (1993) Eur. J. Biochem. 214, 141-146). Recombinant human PAI-2 was labeled with [14C]putrescine catalyzed by guinea pig liver… CONTINUE READING

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