A unique hybrid renal mononuclear phagocyte activation phenotype in murine systemic lupus erythematosus nephritis.

@article{Bethunaickan2011AUH,
  title={A unique hybrid renal mononuclear phagocyte activation phenotype in murine systemic lupus erythematosus nephritis.},
  author={Ramalingam Bethunaickan and Celine C Berthier and Meera Ramanujam and Ranjit K Sahu and Weijia Zhang and Yezou Sun and Erwin P. Bottinger and Lionel B. Ivashkiv and Matthias Kretzler and Anne Davidson},
  journal={Journal of immunology},
  year={2011},
  volume={186 8},
  pages={
          4994-5003
        }
}
Renal infiltration with mononuclear cells is associated with poor prognosis in systemic lupus erythematosus. A renal macrophage/dendritic cell signature is associated with the onset of nephritis in NZB/W mice, and immune-modulating therapies can reverse this signature and the associated renal damage despite ongoing immune complex deposition. In nephritic NZB/W mice, renal F4/80(hi)/CD11c(int) macrophages are located throughout the interstitium, whereas F4/80(lo)/CD11c(hi) dendritic cells… CONTINUE READING

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