A unique function for LRP-1: a component of a two-receptor system mediating specific endocytosis of plasma-derived factor V by megakaryocytes.

@article{Bouchard2008AUF,
  title={A unique function for LRP-1: a component of a two-receptor system mediating specific endocytosis of plasma-derived factor V by megakaryocytes.},
  author={Beth A Bouchard and Natalie T. Meisler and Michael E. Nesheim and C Liu and Dudley K Strickland and Paula B. Tracy},
  journal={Journal of thrombosis and haemostasis : JTH},
  year={2008},
  volume={6 4},
  pages={638-44}
}
BACKGROUND Factor V is endocytosed by megakaryocytes from plasma via a specific, receptor-mediated, clathrin-dependent mechanism to form the unique platelet-derived FV pool. OBJECTIVE The role of low-density lipoprotein (LDL) receptor-related protein-1 (LRP-1), or a related family member, in FV endocytosis by megakaryocytes was examined because of its known interactions with other proteins involved in hemostasis. METHODS LRP-1 expression by megakaryocytes and its functional role in FV… CONTINUE READING
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