A unique central tryptophan hydroxylase isoform.

@article{Walther2003AUC,
  title={A unique central tryptophan hydroxylase isoform.},
  author={Diego J. Walther and Michael Bader},
  journal={Biochemical pharmacology},
  year={2003},
  volume={66 9},
  pages={
          1673-80
        }
}
Phenylalanine hydroxylase contributes to serotonin synthesis in mice
TLDR
Evidence is provided by the gain and loss of function approaches in in vitro and in vivo systems, including stable‐isotope tracing in mice, that phenylalanine hydroxylase (PAH) is a third TPH in mammals and contributes to serotonin levels in the blood.
Inhibition of Tryptophan Hydroxylases and Monoamine Oxidase-A by the Proton Pump Inhibitor, Omeprazole—In Vitro and In Vivo Investigations
TLDR
The MAO-A inhibition afforded by high-dose omeprazole appears to overcome the opposing effect on 5-HT produced by inhibition of TPH1 and TPH2, and further modification of proton pump inhibitor scaffolds may yield more selective modulators of 5- HT metabolism.
Tryptophan Hydroxylase as Novel Target for the Treatment of Depressive Disorders
TLDR
The data which support TPH2 as novel drug target are summarized and strategies for its pharmacological exploitation are discussed.
Funktionelle Charakterisierung der humanen Tryptophanhydroxylase 2
TLDR
It was shown that T PH2 is not only expressed in the central nervous system but also in the testis and that TPH1 and 2 not only differ in their expression sites butAlso in their basic biochemical characteristics, and the expression of T PH1 mRNA was identified as a marker for endometrial cancer.
5‐HYDROXYTRYPTAMINE IN THE CARDIOVASCULAR SYSTEM: FOCUS ON THE SEROTONIN TRANSPORTER (SERT)
  • W. Ni, S. Watts
  • Biology
    Clinical and experimental pharmacology & physiology
  • 2006
TLDR
The function of SERT in the CV system is just beginning to be revealed, but includes modulation of cardiac and smooth muscle contractility, platelet aggregation, cellular mitogenesis, modulating neuronal activity and urinary excretion.
Stress inhibits tryptophan hydroxylase expression in a rat model of depression.
TLDR
Stress was able to inhibit expression of TPH1/2 in brain tissue and decrease concentration of 5-HT, the mechanism maybe involve in increasing the methylation of T PH2 genes promoter; Paroxetine has a role in confronting the effect of stress in depressive rat model.
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