A unique central tryptophan hydroxylase isoform.

  title={A unique central tryptophan hydroxylase isoform.},
  author={Diego J. Walther and Michael Bader},
  journal={Biochemical pharmacology},
  volume={66 9},
Phenylalanine hydroxylase contributes to serotonin synthesis in mice
Evidence is provided by the gain and loss of function approaches in in vitro and in vivo systems, including stable‐isotope tracing in mice, that phenylalanine hydroxylase (PAH) is a third TPH in mammals and contributes to serotonin levels in the blood.
Inhibition of Tryptophan Hydroxylases and Monoamine Oxidase-A by the Proton Pump Inhibitor, Omeprazole—In Vitro and In Vivo Investigations
The MAO-A inhibition afforded by high-dose omeprazole appears to overcome the opposing effect on 5-HT produced by inhibition of TPH1 and TPH2, and further modification of proton pump inhibitor scaffolds may yield more selective modulators of 5- HT metabolism.
Tryptophan Hydroxylase as Novel Target for the Treatment of Depressive Disorders
The data which support TPH2 as novel drug target are summarized and strategies for its pharmacological exploitation are discussed.
Funktionelle Charakterisierung der humanen Tryptophanhydroxylase 2
It was shown that T PH2 is not only expressed in the central nervous system but also in the testis and that TPH1 and 2 not only differ in their expression sites butAlso in their basic biochemical characteristics, and the expression of T PH1 mRNA was identified as a marker for endometrial cancer.
  • W. Ni, S. Watts
  • Biology
    Clinical and experimental pharmacology & physiology
  • 2006
The function of SERT in the CV system is just beginning to be revealed, but includes modulation of cardiac and smooth muscle contractility, platelet aggregation, cellular mitogenesis, modulating neuronal activity and urinary excretion.
Stress inhibits tryptophan hydroxylase expression in a rat model of depression.
Stress was able to inhibit expression of TPH1/2 in brain tissue and decrease concentration of 5-HT, the mechanism maybe involve in increasing the methylation of T PH2 genes promoter; Paroxetine has a role in confronting the effect of stress in depressive rat model.


Eating disorder and epilepsy in mice lacking 5-HT2C serotonin receptors
It is shown that 5-HT2C receptor-deficient mice are overweight as a result of abnormal control of feeding behaviour, establishing a role for this receptor in the serotonergic control of appetite.
Synthesis of Serotonin by a Second Tryptophan Hydroxylase Isoform
The neurotransmitter serotonin [5-hydroxytryptamine (5-HT)] is causally involved in multiple central nervous facets of mood control and in regulating sleep, anxiety, alcoholism, drug abuse, food
Melatonin Effects on Serotonin Synthesis and Metabolism in the Striatum, Nucleus Accumbens, and Dorsal and Median Raphe Nuclei of Rats
The pineal gland, through the secretion of melatonin, modulates the local metabolism of 5-HT in forebrain areas by acting on the oxidative deamination, and melatonin injected in pinealectomized rats derives in a more extended effect than pinealectomy and induces a stimulation of5-HT synthesis in the striatum, probably due to a pharmacological effect.
Tryptophan hydroxylation in brain.
  • D. Grahame-Smith
  • Biology, Chemistry
    Biochemical and biophysical research communications
  • 1964
Suicidality and 5-hydroxyindoleacetic acid concentration associated with a tryptophan hydroxylase polymorphism.
In some individuals, a genetic variant of the TPH gene may influence 5-HIAA concentration in the cerebrospinal fluid and predisposition to suicidal behavior.
Increased anxiety of mice lacking the serotonin1A receptor.
It is hypothesize that an increased serotonergic neurotransmission is responsible for the anxiety-like behavior of receptor-deficient animals, consistent with earlier studies showing that pharmacological activation of the 5-HT system is anxiogenic in animal models and also in humans.
Pools of serotonin in the pineal gland of the mouse: The mammalian pinealocyte as a component of the diffuse neuroendocrine system
The distribution of serotonin (5-HT) and its eventual relationships to a protein secretion were examined by means of fluorescence histochemical and ultracytochemical methods andYellow formaldehyde-induced fluorophores, characteristic of high concentrations of 5-HT, were found in pinealocytes, interstitial cells and sympathetic adrenergic nerve endings.
Evidence for involvement of protein kinases in the regulation of serotonin synthesis and turnover in the mouse brain in vivo
The results indicate that activation of tryptophan hydroxylase by reducing the tone from terminal 5-HT1B receptors involves PKA whereas the depolarisation-induced activation oftryptophansulfonamide involves CaM kinase II.