A unique, short sequence determines p53 gene basal and UV-inducible expression in normal human cells

@article{Noda2000AUS,
  title={A unique, short sequence determines p53 gene basal and UV-inducible expression in normal human cells},
  author={Asao Noda and Yumiko Toma-Aiba and Yoshisada Fujiwara},
  journal={Oncogene},
  year={2000},
  volume={19},
  pages={21-31}
}
The p53 tumor suppressor protein plays a central role in the cellular defence against agents which cause genetic damage. The induction and activation of p53 upon stress has been shown at post-transcription level by multiple mechanisms, while the regulatory role of p53 gene transcription is still poorly understood. Here we show that the causative mechanisms underlying this activation are attributed in part to the promoter function of p53. In various normal human cells, p53 gene expression is… CONTINUE READING

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