A unique, highly conserved secretory invertase is differentially expressed by promastigote developmental forms of all species of the human pathogen, Leishmania

@article{Lyda2015AUH,
  title={A unique, highly conserved secretory invertase is differentially expressed by promastigote developmental forms of all species of the human pathogen, Leishmania},
  author={Todd A Lyda and Manju B. Joshi and John F. Andersen and Andrew Y. Kelada and Joshua P. Owings and Paul A. Bates and Dennis M. Dwyer},
  journal={Molecular and Cellular Biochemistry},
  year={2015},
  volume={404},
  pages={53-77}
}
Leishmania are protozoan pathogens of humans that exist as extracellular promastigotes in the gut of their sand fly vectors and as obligate intracellular amastigotes within phagolysosomes of infected macrophages. Between infectious blood meal feeds, sand flies take plant juice meals that contain sucrose and store these sugars in their crop. Such sugars are regurgitated into the sand fly anterior midgut where they impact the developing promastigote parasite population. In this report we showed… CONTINUE READING