A unifying paradigm for naphthoquinone-based meroterpenoid (bio)synthesis.

  title={A unifying paradigm for naphthoquinone-based meroterpenoid (bio)synthesis.},
  author={Zachary Miles and Stefan Diethelm and Henry P Pepper and David M Huang and Jonathan H George and Bradley S Moore},
  journal={Nature chemistry},
  volume={9 12},
Bacterial meroterpenoids constitute an important class of natural products with diverse biological properties and therapeutic potential. The biosynthetic logic for their production is unknown and defies explanation via classical biochemical paradigms. A large subgroup of naphthoquinone-based meroterpenoids exhibits a substitution pattern of the polyketide-derived aromatic core that seemingly contradicts the established reactivity pattern of polyketide phenol nucleophiles and terpene diphosphate… CONTINUE READING


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