A unified physiological framework of transitions between seizures, status epilepticus and depolarization block at the single neuron level

  title={A unified physiological framework of transitions between seizures, status epilepticus and depolarization block at the single neuron level},
  author={Damien Depannemaecker and Anton I. Ivanov and Davide Lillo and Len Spek and Christophe Bernard and Viktor Jirsa},
The majority of seizures recorded in humans and experimental animal models can be described by a generic phenomenological mathematical model, The Epileptor. In this model, seizure-like events (SLEs) are driven by a slow variable and occur via saddle node (SN) and homoclinic bifurcations at seizure onset and offset, respectively. Here we investigated SLEs at the single cell level using a biophysically relevant neuron model including a slow/fast system of four equations. The two equations for the… 

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Simulated seizures and spreading depression in a neuron model incorporating interstitial space and ion concentrations.

It is concluded that epileptiform neuronal behavior and SD-like depolarization can be generated by the feedback of ion currents that change ion concentrations, which, in turn, influence ion currents and membrane potentials.

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