A unified architecture of transcriptional regulatory elements.

@article{Andersson2015AUA,
  title={A unified architecture of transcriptional regulatory elements.},
  author={Robin Andersson and Albin Sandelin and Charles G. Danko},
  journal={Trends in genetics : TIG},
  year={2015},
  volume={31 8},
  pages={426-33}
}
Gene expression is precisely controlled in time and space through the integration of signals that act at gene promoters and gene-distal enhancers. Classically, promoters and enhancers are considered separate classes of regulatory elements, often distinguished by histone modifications. However, recent studies have revealed broad similarities between enhancers and promoters, blurring the distinction: active enhancers often initiate transcription, and some gene promoters have the potential to… CONTINUE READING
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