A unified anti-mutant dosing strategy.

@article{Zhao2008AUA,
  title={A unified anti-mutant dosing strategy.},
  author={Xilin Zhao and Karl Drlica},
  journal={The Journal of antimicrobial chemotherapy},
  year={2008},
  volume={62 3},
  pages={434-6}
}
Antimicrobial dosing is currently attracting attention as a way to minimize the emergence of resistance. Three dose-based strategies have been advocated, each with shortcomings. Focus on killing susceptible cells overlooks resistant mutant subpopulations that may be present before treatment or generated during therapy; keeping therapeutic drug concentrations above the mutant prevention concentration (MPC; resistant mutant MIC) may be overly stringent; and dosage escalation modelling uses… CONTINUE READING

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An anti-mutant approach for antimicrobial use

  • K Drlica, X Zhao, JY Wang
  • 2008

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