• Corpus ID: 33922397

A ubiquitin ligase HRD 1 promotes the degradation of Pael receptor , a substrate of

@inproceedings{Omura2017AUL,
  title={A ubiquitin ligase HRD 1 promotes the degradation of Pael receptor , a substrate of},
  author={Tomohiro Omura and Masayuki Kaneko and Yasunobu Okuma and Yasuko Orba and Kazuo Nagashima and Ryosuke Takahashi and Noboru Fujitani and Satoshi Matsumura and Akihisa Hata and Kyoko Kubota and Karin Murahashi and Takashi Uehara and Yasuyuki Nomura},
  year={2017}
}
It has been proposed that in autosomal recessive juvenile parkinsonism (AR-JP), a ubiquitin ligase (E3) Parkin, which is involved in endoplasmic reticulum (ER)-associated degradation (ERAD), lacks E3 activity. The resulting accumulation of Parkin-associated endothelin receptor-like receptor (Pael-R), a substrate of Parkin, leads to ER stress, causing neuronal death. We previously reported that human E3 HRD1 in the ER protects against ER stress-induced apoptosis. This study shows that (1) HRD1… 

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Parkin Suppresses Unfolded Protein Stress-induced Cell Death through Its E3 Ubiquitin-protein Ligase Activity*
TLDR
It is demonstrated that Parkin is an E3 enzyme and suggested that it is involved in the ubiquitination pathway for misfolded proteins derived from endoplasmic reticulum and contributes to protection from neurotoxicity induced by unfolded protein stresses.
Human HRD1 protects against ER stress‐induced apoptosis through ER‐associated degradation1
TLDR
The identification and characterization of a human homolog to yeast Hrd1p is reported, which suggests that the production of HRD1 is up‐regulated to protect against ER stress‐induced apoptosis by degrading unfolded proteins accumulated in the ER.
Human HRD1 Is an E3 Ubiquitin Ligase Involved in Degradation of Proteins from the Endoplasmic Reticulum*
TLDR
The structure and function of the putative human orthologue of yeast Hrd1p/Der3p, designated human HRD1, is characterized, showing that humanHRD1 is a non-glycosylated, stable ER protein with a cytosolic RING-H2 finger domain, suggesting that human HRd1 is an E3 ubiquitin ligase involved in protein degradation.
An Unfolded Putative Transmembrane Polypeptide, which Can Lead to Endoplasmic Reticulum Stress, Is a Substrate of Parkin
TLDR
It is shown that the unfolded Pael receptor is a substrate of Parkin, the accumulation of which may cause selective neuronal death in AR-JP.
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TLDR
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TLDR
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TLDR
This study shows in an organismal system that panneuronal expression of Parkin substrate Pael-R causes age-dependent selective degeneration of Drosophila dopaminergic neurons and suggests that manipulating Parkin expression may provide a novel avenue of PD therapy.
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TLDR
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TLDR
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