A tyrosine-based motif localizes a Drosophila vesicular transporter to synaptic vesicles in vivo.

@article{Grygoruk2010ATM,
  title={A tyrosine-based motif localizes a Drosophila vesicular transporter to synaptic vesicles in vivo.},
  author={Anna Grygoruk and Hao Fei and Richard W. Daniels and Bradley R. Miller and Aaron Diantonio and David E. Krantz},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 10},
  pages={6867-78}
}
Vesicular neurotransmitter transporters must localize to synaptic vesicles (SVs) to allow regulated neurotransmitter release at the synapse. However, the signals required to localize vesicular proteins to SVs in vivo remain unclear. To address this question we have tested the effects of mutating proposed trafficking domains in Drosophila orthologs of the vesicular monoamine and glutamate transporters, DVMAT-A and DVGLUT. We show that a tyrosine-based motif (YXXY) is important both for DVMAT-A… CONTINUE READING