A-type lamins bind both hetero- and euchromatin, the latter being regulated by lamina-associated polypeptide 2 alpha.

@article{Gesson2016AtypeLB,
  title={A-type lamins bind both hetero- and euchromatin, the latter being regulated by lamina-associated polypeptide 2 alpha.},
  author={Kevin Gesson and Philipp Rescheneder and Michael P Skoruppa and Arndt von Haeseler and Thomas Dechat and Roland Foisner},
  journal={Genome research},
  year={2016},
  volume={26 4},
  pages={
          462-73
        }
}
Lamins are components of the peripheral nuclear lamina and interact with heterochromatic genomic regions, termed lamina-associated domains (LADs). In contrast to lamin B1 being primarily present at the nuclear periphery, lamin A/C also localizes throughout the nucleus, where it associates with the chromatin-binding protein lamina-associated polypeptide (LAP) 2 alpha. Here, we show that lamin A/C also interacts with euchromatin, as determined by chromatin immunoprecipitation of euchromatin- and… CONTINUE READING
Highly Cited
This paper has 18 citations. REVIEW CITATIONS
Tweets
This paper has been referenced on Twitter 4 times. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 12 citations