A type IV pilin, PilA, Contributes To Adherence of Burkholderia pseudomallei and virulence in vivo.

@article{EssexLopresti2005ATI,
  title={A type IV pilin, PilA, Contributes To Adherence of Burkholderia pseudomallei and virulence in vivo.},
  author={Angela E. Essex-Lopresti and Justin A Boddey and Richard Thomas and Martin P Smith and M. Gill Hartley and Timothy P. Atkins and Nat F. Brown and Chuk Hai Tsang and Ian R A Peak and Jim Hill and Ifor R. Beacham and Richard W. Titball},
  journal={Infection and immunity},
  year={2005},
  volume={73 2},
  pages={1260-4}
}
The Burkholderia pseudomallei K96243 genome contains multiple type IV pilin-associated loci, including one encoding a putative pilus structural protein (pilA). A pilA deletion mutant has reduced adherence to human epithelial cells and is less virulent in the nematode model of virulence and the murine model of melioidosis, suggesting a role for type IV pili in B. pseudomallei virulence.