A type IB topoisomerase with DNA repair activities

@article{Belova2001ATI,
  title={A type IB topoisomerase with DNA repair activities},
  author={Galina I. Belova and Rajendra Prasad and Sergei A. Kozyavkin and James Alan Lake and S. H. Wilson and Alexei I. Slesarev},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98},
  pages={6015 - 6020}
}
Previously we have characterized type IB DNA topoisomerase V (topo V) in the hyperthermophile Methanopyrus kandleri. The enzyme has a powerful topoisomerase activity and is abundant in M. kandleri. Here we report two characterizations of topo V. First, we found that its N-terminal domain has sequence homology with both eukaryotic type IB topoisomerases and the integrase family of tyrosine recombinases. The C-terminal part of the sequence includes 12 repeats, each repeat consisting of two… 

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