A two-year dietary carcinogenicity study of (2R,4R)-monatin salt in mice.

  title={A two-year dietary carcinogenicity study of (2R,4R)-monatin salt in mice.},
  author={Witty A Brathwaite and Christine M Crincoli and Alex Eapen and Marisa O Rihner and Andrey I Nikiforov and Catherine A Picut},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
Groups of Crl:CD-1 (ICR) mice (60/group/sex) were fed 0 (2 control groups), 5000, 20,000, or 40,000 ppm of enzymatically sourced (2R,4R)-monatin salt ("R,R-monatin") in the diet for up to two years. There were no adverse effects on survival, incidence of palpable masses and tumors, feed consumption, hematology or serum chemistry parameters, organ weights, or ophthalmic, macroscopic, and microscopic examinations. The only notable effect was statistically significantly lower mean body weights and… CONTINUE READING