A two-way street: reciprocal regulation of metabolism and signalling

@article{Wellen2012ATS,
  title={A two-way street: reciprocal regulation of metabolism and signalling},
  author={K. Wellen and C. Thompson},
  journal={Nature Reviews Molecular Cell Biology},
  year={2012},
  volume={13},
  pages={270-276}
}
It is becoming increasingly clear that cellular signalling and metabolism are not just separate entities but rather are tightly linked. Although nutrient metabolism is known to be regulated by signal transduction, an emerging paradigm is that signalling and transcriptional networks can be modulated by nutrient-sensitive protein modifications, such as acetylation and glycosylation, which depend on the availability of acetyl-CoA and sugar donors such as UDP-N-acetylglucosamine (UDP-GlcNAc… Expand
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