A two-tiered mechanism of EGFR inhibition by RALT/MIG6 via kinase suppression and receptor degradation

@inproceedings{Frosi2010ATM,
  title={A two-tiered mechanism of EGFR inhibition by RALT/MIG6 via kinase suppression and receptor degradation},
  author={Yuri Frosi and Sergio Anastasi and Costanza Ballar{\`o} and Giulia Varsano and Loriana Castellani and Elena Maspero and Simona Polo and Stefano Alem{\`a} and Oreste Segatto},
  booktitle={The Journal of cell biology},
  year={2010}
}
Signaling by epidermal growth factor receptor (EGFR) must be controlled tightly because aberrant EGFR activity may cause cell transformation. Receptor-associated late transducer (RALT) is a feedback inhibitor of EGFR whose genetic ablation in the mouse causes phenotypes due to EGFR-driven excess cell proliferation. RALT inhibits EGFR catalytic activation by docking onto EGFR kinase domain. We report here an additional mechanism of EGFR suppression mediated by RALT, demonstrating that RALT-bound… CONTINUE READING

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