A two-step nucleotide-flipping mechanism enables kinetic discrimination of DNA lesions by AGT.

@article{Hu2008ATN,
  title={A two-step nucleotide-flipping mechanism enables kinetic discrimination of DNA lesions by AGT.},
  author={Jie Hu and Ao Ma and Aaron R. Dinner},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 12},
  pages={4615-20}
}
O(6)-alkylguanine-DNA alkyltransferase (AGT) repairs damage to the human genome by flipping guanine and thymine bases into its active site for irreversible transfer of alkyl lesions to Cys-145, but how the protein identifies its targets has remained unknown. Understanding molecular recognition in this system, which can serve as a paradigm for the many nucleotide-flipping proteins that regulate genes and repair DNA in all kingdoms of life, is particularly important given that inhibitors are in… CONTINUE READING

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