A two-step adhesion cascade for T cell/endothelial cell interactions under flow conditions.

@article{Jones1994ATA,
  title={A two-step adhesion cascade for T cell/endothelial cell interactions under flow conditions.},
  author={D. A. Jones and Larry V. McIntire and C. Wayne Smith and L. Picker},
  journal={The Journal of clinical investigation},
  year={1994},
  volume={94 6},
  pages={
          2443-50
        }
}
Neutrophil adherence to endothelial cells (ECs) under conditions of flow occurs in successive steps, including selectin-dependent primary adhesion and CD18-dependent secondary adhesion. We used a parallel-plate flow chamber to assess the steps in T cell adherence in vitro. On monolayers of L cells transfected with the EC adhesion molecules E-selectin, vascular cell adhesion molecule-1 (VCAM-1), or intercellular adhesion molecule-1 (ICAM-1), E-selectin was capable of mediating only primary… 
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L-selectin-dependent leukocyte adhesion to microvascular but not to macrovascular endothelial cells of the human coronary system.
TLDR
The prolonged time course of L-selectin dependent adhesion suggests a role in sustained leukocyte recruitment into inflammatory sites in vivo, and microvascular, but not macrovascular endothelial cells express TNF-alpha-inducible sulfated ligand(s) for L- Selectin, which differ from known L- selectin ligands, because sialylation is not required.
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