A two-step, PU.1-dependent mechanism for developmentally regulated chromatin remodeling and transcription of the c-fms gene.

@article{Krysinska2007ATP,
  title={A two-step, PU.1-dependent mechanism for developmentally regulated chromatin remodeling and transcription of the c-fms gene.},
  author={Hanna Krysinska and Maarten Hoogenkamp and Richard Ingram and Nicola C Wilson and Hiromi Tagoh and Peter Laslo and Harinder Singh and Constanze Bonifer},
  journal={Molecular and cellular biology},
  year={2007},
  volume={27 3},
  pages={878-87}
}
Hematopoietic stem cells and multipotent progenitors exhibit low-level transcription and partial chromatin reorganization of myeloid cell-specific genes including the c-fms (csf1R) locus. Expression of the c-fms gene is dependent on the Ets family transcription factor PU.1 and is upregulated during myeloid differentiation, enabling committed macrophage precursors to respond to colony-stimulating factor 1. To analyze molecular mechanisms underlying the transcriptional priming and developmental… CONTINUE READING

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