A two-stage binomial test approach of gene identification in oligonucleotide arrays.

@article{Chen2007ATB,
  title={A two-stage binomial test approach of gene identification in oligonucleotide arrays.},
  author={Dung-Tsa Chen and James J. Chen and Gary C. Cheng and Sue-Hwa Lin and Seng-jaw Soong},
  journal={Journal of biopharmaceutical statistics},
  year={2007},
  volume={17 5},
  pages={903-18}
}
Most statistical approaches summarize the probe-level expression data into gene-level measures, which then are used for downstream statistical analyses. However, there are some limitations in using the gene level data for analysis, such as nonhomogeneous probe effects and the interaction effect (e.g., alternative splicing). In this paper, we consider a two… CONTINUE READING