A two-nucleotide deletion renders the mannose-binding lectin 2 (MBL2) gene nonfunctional in Danish Landrace and Duroc pigs

@article{Bergman2014ATD,
  title={A two-nucleotide deletion renders the mannose-binding lectin 2 (MBL2) gene nonfunctional in Danish Landrace and Duroc pigs},
  author={I. M. Bergman and Kjell Edman and P. van As and Abe Huisman and Helle Risdahl Juul-Madsen},
  journal={Immunogenetics},
  year={2014},
  volume={66},
  pages={171-184}
}
The mannose-binding lectins (MBLs) are central components of innate immunity, facilitating phagocytosis and inducing the lectin activation pathway of the complement system. Previously, it has been found that certain single-nucleotide polymorphisms (SNPs) in porcine MBL1 and MBL2 (pMBL1, pMBL2) affect mRNA expression, serum concentration, and susceptibility… CONTINUE READING