A two-module region of the low-density lipoprotein receptor sufficient for formation of complexes with apolipoprotein E ligands.

@article{Fisher2004ATR,
  title={A two-module region of the low-density lipoprotein receptor sufficient for formation of complexes with apolipoprotein E ligands.},
  author={Carl Erik Fisher and Dunia Abdul-Aziz and Stephen C Blacklow},
  journal={Biochemistry},
  year={2004},
  volume={43 4},
  pages={1037-44}
}
The low-density lipoprotein (LDL) receptor transports two different classes of cholesterol-carrying lipoprotein particles into cells: LDL particles, which contain a single copy of apolipoprotein B-100 (apoB-100), and beta-migrating very low-density lipoprotein (beta-VLDL) particles, which contain multiple copies of apolipoprotein E (apoE). The ligand-binding domain of the receptor lies at its amino-terminal end within seven adjacent LDL-A repeats (LA1-LA7). Although prior work clearly… CONTINUE READING

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