A two-hybrid screen identifies cathepsins B and L as uncoating factors for adeno-associated virus 2 and 8.

Abstract

Vectors based on different serotypes of adeno-associated virus hold great promise for human gene therapy, based on their unique tissue tropisms and distinct immunological profiles. A particularly interesting candidate is AAV8, which can efficiently and rapidly transduce a wide range of tissues in vivo. To further unravel the mechanisms behind AAV8… (More)

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@article{Akache2007ATS, title={A two-hybrid screen identifies cathepsins B and L as uncoating factors for adeno-associated virus 2 and 8.}, author={Bassel Akache and Dirk Grimm and Xuan Shen and Sally Fuess and Stephen R. Yant and Dariya S. Glazer and Julie E Park and Mark A. Kay}, journal={Molecular therapy : the journal of the American Society of Gene Therapy}, year={2007}, volume={15 2}, pages={330-9} }