A two-generation reproductive toxicity study of dicyclohexyl phthalate in rats.

@article{Hoshino2005ATR,
  title={A two-generation reproductive toxicity study of dicyclohexyl phthalate in rats.},
  author={Nobuhito Hoshino and Mayumi Iwai and Yoshimasa Okazaki},
  journal={The Journal of toxicological sciences},
  year={2005},
  volume={30 Spec No.},
  pages={79-96}
}
The reproductive toxicity of dicyclohexyl phthalate (DCHP) was evaluated in a two generation test in which male and female Sprague-Dawley (SD) rats of parental (F0) and F1 generation were exposed to DCHP in the diet at concentrations of 0 (control), 240, 1200 or 6000 ppm. With regard to the effects on the F0 and F1 parental animals, changes included inhibition of body weight gain and food consumption, diffuse hypertrophy of hepatocytes, and hypertrophy of thyroidal follicular epithelial cells… CONTINUE READING