A two-generation reproductive toxicity study of 2,4-dichlorophenol in rats.

@article{Aoyama2005ATR,
  title={A two-generation reproductive toxicity study of 2,4-dichlorophenol in rats.},
  author={Hiroaki Aoyama and Hitoshi Hojo and Ken L. Takahashi and Naoko Shimizu and Masayuki Araki and Michiko Harigae and Naoki Tanaka and Noriko Shirasaka and Maki Kuwahara and Nobuaki Nakashima and Eri Yamamoto and Machiko Saka and Shoji Teramoto},
  journal={The Journal of toxicological sciences},
  year={2005},
  volume={30 Spec No.},
  pages={
          59-78
        }
}
A two-generation reproductive toxicity study was conducted with 2,4-dichlorophenol (2,4-DCP), an agent suspected of exerting endocrine disrupting effects. Wistar-Hannover rats, 24/sex/group, were given diet containing 2,4-DCP at dose levels of 0, 500, 2000 or 8000 ppm to examine the potential effects of the test substance on parental animals and their offspring over 2 successive generations. Neither clear systemic nor reproductive toxicity of 2,4-DCP was apparent in the 500 ppm group. In the… CONTINUE READING

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