A two-dimensional NMR study of the antimicrobial magainin 2

Abstract

Using two-dimensional NMR spectroscopy, a complete ‘H resonance assignment has been obtained for the peptide magaining 2 recently isolated from Xenopus luevis. It is demonstrated that this peptide adopts an a-helical structure with amphiphilic character when dissolved in a mixture of trifluoroethanol (TFE) and HrO. The transition to the cc-helical… (More)

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