A two-component Kdo hydrolase in the inner membrane of Francisella novicida.

@article{Zhao2010ATK,
  title={A two-component Kdo hydrolase in the inner membrane of Francisella novicida.},
  author={Jinshi Zhao and Christian R. H. Raetz},
  journal={Molecular microbiology},
  year={2010},
  volume={78 4},
  pages={820-36}
}
Lipid A coats the outer surface of the outer membrane of Gram-negative bacteria. In Francisella tularensis subspecies novicida lipid A is present either as the covalently attached anchor of lipopolysaccharide (LPS) or as free lipid A. The lipid A moiety of Francisella LPS is linked to the core domain by a single 2-keto-3-deoxy-D-manno-octulosonic acid (Kdo) residue. F. novicida KdtA is bi-functional, but F. novicida contains a membrane-bound Kdo hydrolase that removes the outer Kdo unit. The… CONTINUE READING
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