A two-cilia model for vertebrate left-right axis specification.

  title={A two-cilia model for vertebrate left-right axis specification.},
  author={Clifford J Tabin and Kyle J. Vogan},
  journal={Genes & development},
  volume={17 1},
The mechanisms underlying vertebrate left-right (L-R) axis specification have attracted much interest among developmental biologists (for review, see Burdine and Schier 2000; Capdevila et al. 2000). Of particular interest from a conceptual standpoint is the question of how L-R positional information first originates within the context of a bilaterally symmetric embryo. To achieve the consistent L-R handedness characteristic of the vertebrate body plan, the L-R axis must be reliably oriented… CONTINUE READING
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