A two-by-two factorial trial comparing oral with transdermal estrogen therapy and fenretinide with placebo on breast cancer biomarkers.

@article{Decensi2004ATF,
  title={A two-by-two factorial trial comparing oral with transdermal estrogen therapy and fenretinide with placebo on breast cancer biomarkers.},
  author={Andrea U. Decensi and Bernardo Bonanni and Laura Baglietto and Aliana Guerrieri-gonzaga and Francesca Ramazzotto and Harriet Johansson and Chris Robertson and Irene Marinucci and Frederique Mariette and Maria Teresa Sandri and Cristina Daldoss and Vanda Bianco and Marco Buttarelli and Massimiliano Cazzaniga and Dorella Franchi and Enrico Cassano and Umberto Omodei},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2004},
  volume={10 13},
  pages={4389-97}
}
PURPOSE Oral conjugated equine estrogen (CEE) and medroxyprogesterone acetate (MPA) increase breast cancer risk, whereas the effect of transdermal estradiol (E2) and MPA is less known. Fenretinide may decrease second breast malignancies in premenopausal women but not in postmenopausal women, suggesting a hormone-sensitizing effect. We compared the 6 and 12-month changes in insulin-like growth factor-I (IGF-I), IGF-binding protein-3 (IGFBP-3), IGF-I:IGFBP-3 ratio, sex-hormone binding-globulin… CONTINUE READING

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