A tunicate (Botryllus schlosseri) cDNA reveals similarity to vertebrate antigen receptors

  title={A tunicate (Botryllus schlosseri) cDNA reveals similarity to vertebrate antigen receptors},
  author={Zeev Pancer and Edwin Cooper and Werner E G M{\"u}ller},
The unique ability of vertebrates to mount specific immune responses relies primarily upon recognition of non-self antigens. While invertebrates possess elaborate mechanisms to recognize self antigens (Cooper et al. 1992; Smith and Davidson 1992; Sima 1993; Humphreys et al. 1994), it appears that the propensity for non-self discrimination by virtue of T-cell receptors (TCR) and antibodies (Ab) evolved later, perhaps after the divergence of jawless and jawed vertebrates (Marchalonis and Schluter… CONTINUE READING


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