A tunable hydrogel system for long-term release of cell-secreted cytokines and bioprinted in situ wound cell delivery.

@article{Skardal2017ATH,
  title={A tunable hydrogel system for long-term release of cell-secreted cytokines and bioprinted in situ wound cell delivery.},
  author={Aleksander Skardal and Sean V Murphy and Kathryn Crowell and David L. Mack and Anthony J Atala and Shay Soker},
  journal={Journal of biomedical materials research. Part B, Applied biomaterials},
  year={2017},
  volume={105 7},
  pages={
          1986-2000
        }
}
For many cellular therapies being evaluated in preclinical and clinical trials, the mechanisms behind their therapeutic effects appear to be the secretion of growth factors and cytokines, also known as paracrine activity. Often, delivered cells are transient, and half-lives of the growth factors that they secrete are short, limiting their long-term effectiveness. The goal of this study was to optimize a hydrogel system capable of in situ cell delivery that could sequester and release growth… CONTINUE READING
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