A tumour suppressor network relying on the polyamine–hypusine axis

  title={A tumour suppressor network relying on the polyamine–hypusine axis},
  author={Claudio Scuoppo and Cornelius Miething and Lisa M Lindqvist and Jos{\'e} Reyes and Cristian I. Ruse and Iris Appelmann and Seungtai Yoon and Alexander Krasnitz and Julie Teruya-Feldstein and Darryl J. Pappin and J. -P. Pelletier and Scott W Lowe},
Tumour suppressor genes encode a broad class of molecules whose mutational attenuation contributes to malignant progression. In the canonical situation, the tumour suppressor is completely inactivated through a two-hit process involving a point mutation in one allele and chromosomal deletion of the other. Here, to identify tumour suppressor genes in lymphoma, we screen a short hairpin RNA library targeting genes deleted in human lymphomas. We functionally identify those genes whose suppression… CONTINUE READING
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