A tumor-targeting near-infrared laser-triggered drug delivery system based on GO@Ag nanoparticles for chemo-photothermal therapy and X-ray imaging.

@article{Shi2014ATN,
  title={A tumor-targeting near-infrared laser-triggered drug delivery system based on GO@Ag nanoparticles for chemo-photothermal therapy and X-ray imaging.},
  author={Jinjin Shi and Lei Wang and Jing Zhang and Rou Ma and Jun Gao and Yan Liu and Chaofeng Zhang and Zhenzhong Zhang},
  journal={Biomaterials},
  year={2014},
  volume={35 22},
  pages={5847-61}
}
In this study, a GO@Ag nanocomposite was synthesized by chemical deposition of Ag nanoparticles onto graphene oxide (GO) through a hydro thermal reaction, and doxorubicin (DOX), one of the most effective drugs against a wide range of cancers, was employed as the model drug and linked to GO@Ag via ester bonds with a very high drug loading efficiency (∼82.0%, weight ratio of DOX/GO@Ag), then GO@Ag-DOX was functionalized by DSPE-PEG2000-NGR, giving GO@Ag-DOX with active tumor-targeting capacity… CONTINUE READING