A tumor suppressor function for the lipid phosphatase INPP4B in melanocytic neoplasms.

@article{PrezLorenzo2014ATS,
  title={A tumor suppressor function for the lipid phosphatase INPP4B in melanocytic neoplasms.},
  author={Rolando P{\'e}rez-Lorenzo and Kamraan Z. Gill and C M Shen and Feng X Zhao and Bin Zheng and H J Schulze and David N. Silvers and Georg Brunner and Basil A. J. Horst},
  journal={The Journal of investigative dermatology},
  year={2014},
  volume={134 5},
  pages={1359-1368}
}
The phosphoinositide-3 kinase (PI3K) pathway is deregulated in a significant proportion of melanomas, and PI3K pathway activation in combination with constitutively active mitogen-activated protein kinase signaling shows synergistic effects in the process of melanoma tumorigenesis. Recently, a tumor suppressor function for the lipid phosphatase inositol polyphosphate 4-phosphatase type II (INPP4B) has been described in breast and prostate cancers, with impact on PI3K signaling output. Given the… CONTINUE READING
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Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers.

Proceedings of the National Academy of Sciences of the United States of America • 2010
View 11 Excerpts
Highly Influenced

Cancer statistics, 2012.

CA: a cancer journal for clinicians • 2012
View 1 Excerpt

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