A tumor-stroma targeted oncolytic adenovirus replicated in human ovary cancer samples and inhibited growth of disseminated solid tumors in mice.

@article{Lpez2012ATT,
  title={A tumor-stroma targeted oncolytic adenovirus replicated in human ovary cancer samples and inhibited growth of disseminated solid tumors in mice.},
  author={Mar{\'i}a Veronica Hern{\'a}ndez L{\'o}pez and Angel A. Rivera and Diego L Viale and Lorena Benedetti and Nicasio C{\'u}neo and Kristopher J. Kimball and Minghui Wang and Joanne T. Douglas and Zeng Bian Zhu and Alicia In{\'e}s Bravo and Manuel Gidekel and R R Douglas Alvarez and David T. Curiel and Osvaldo L. Podhajcer},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2012},
  volume={20 12},
  pages={
          2222-33
        }
}
  • María Veronica Hernández López, Angel A. Rivera, +11 authors Osvaldo L. Podhajcer
  • Published in
    Molecular therapy : the…
    2012
  • Biology, Medicine
  • Targeting the tumor stroma in addition to the malignant cell compartment is of paramount importance to achieve complete tumor regression. In this work, we modified a previously designed tumor stroma-targeted conditionally replicative adenovirus (CRAd) based on the SPARC promoter by introducing a mutated E1A unable to bind pRB and pseudotyped with a chimeric Ad5/3 fiber (Ad F512v1), and assessed its replication/lytic capacity in ovary cancer in vitro and in vivo. AdF512v1 was able to replicate… CONTINUE READING

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