A tryptophan hydroxylase gene marker for suicidality and alcoholism.

  title={A tryptophan hydroxylase gene marker for suicidality and alcoholism.},
  author={D A Nielsen and Matti Virkkunen and Jani Lappalainen and Marlene Eggert and Gerald L. Brown and Jeffrey C. Long and David Goldman and Markku Linnoila},
  journal={Archives of general psychiatry},
  volume={55 7},
BACKGROUND Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the synthesis of serotonin. Low turnover rate of this monoamine neurotransmitter is associated with impaired impulse control. We previously reported that, in Finns, TPH genotype was associated with suicidality, a pathophysiological mechanism that may involve impaired impulse control. METHODS Association and sib-pair linkage analyses of a polymorphism in intron 7 of the TPH gene with suicidality, alcoholism, and the… CONTINUE READING
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