A trypanosome-soluble factor induces IP3 formation, intracellular Ca2+ mobilization and microfilament rearrangement in host cells

@article{Rodrguez1995ATF,
  title={A trypanosome-soluble factor induces IP3 formation, intracellular Ca2+ mobilization and microfilament rearrangement in host cells},
  author={Ana Rodr{\'i}guez and Marc G. Rioult and Ari Ora and Norma W Andrews},
  journal={The Journal of Cell Biology},
  year={1995},
  volume={129},
  pages={1263 - 1273}
}
Lysosomes are recruited to the invasion site during host cell entry by Trypanosoma cruzi, an unusual process suggestive of the triggering of signal transduction mechanisms. Previous studies showed that trypomastigotes, but not the noninfective epimastigotes, contain a proteolytically generated trypomastigote factor (PGTF) that induces intracellular free Ca2+ transients in several mammalian cell types. Using confocal time-lapse imaging of normal rat kidney (NRK) fibroblasts loaded with the Ca(2… CONTINUE READING
56 Citations
50 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 56 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 50 references

Evidence that agonists

  • T. J. Hallam, R. Jacob, E. Merrit
  • 1988
Highly Influential
2 Excerpts

Similar Papers

Loading similar papers…