A trypanosomatid protein specifically interacts with a mammalian iron-responsive element

@article{Meehan2000ATP,
  title={A trypanosomatid protein specifically interacts with a mammalian iron-responsive element},
  author={Heather A. Meehan and Richard A. Lundberg and Gregory J Connell},
  journal={Parasitology Research},
  year={2000},
  volume={86},
  pages={109-114}
}
Intracellular iron homeostasis of vertebrates and invertebrates is mediated through the interaction of iron-regulatory proteins (IRPs) with mRNAs containing a bulged hairpin-loop structure termed the iron-responsive element (IRE). We detected a protein within extracts prepared from Leishmania tarentolae that specifically interacts with a mammalian IRE; mutations to the IRE that inhibit the interaction with the mammalian protein have a corresponding effect on the interaction with the L… CONTINUE READING

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